春天来了
小蜜蜂也出来了
梨花、杏花、桃花都开了

维康药业(300878.SZ):收到黄甲软肝颗粒Ⅱ期临床试验总结报告

格隆汇11月2日丨维康药业(300878.SZ)公布,公司于近日收到《以安慰剂为平行对照评价黄甲软肝颗粒治疗慢性乙型病毒性肝炎肝纤维化(肝郁脾虚兼瘀血阻络证)有效性和安全性的加载、随机、双盲、多中心Ⅱ期临床试验总结报告》。

用于评价肝纤维的金标准为肝组织学,黄甲软肝颗粒临床研究结果显示在肝组织学评价上,高剂量组较低剂量组更能明显改善肝纤维化程度,同时在肝功能指标(ALT、AST)、APRI评分指标、血清肝纤维化标志物(HA、PⅢP)、中医证候指标、中医单项症状指标(胁肋刺痛)等评价方面均体现了显著的疗效差异。表明黄甲软肝颗粒可显著改善慢性乙型病毒性肝炎肝纤维化(肝郁脾虚兼瘀血阻络证),高剂量组疗效更佳。黄甲软肝颗粒治疗慢性乙型病毒性肝炎肝纤维化(肝郁脾虚兼瘀血阻络证)具有良好的临床疗效和安全性,患者的临床获益超过潜在风险。

国内商品期货夜盘开盘焦炭涨0.58%证券时报e公司讯,国内商品期货夜盘开盘涨跌不一,沪银涨0.43%,螺纹跌0.16%,铁矿涨0.27%,焦炭涨0.58%,原油跌0.51%,燃油跌0.64%,橡胶涨0.25%

快讯摘要

国内商品期货夜盘开盘焦炭涨0.58%证券时报e公司讯,国内商品期货夜盘开盘涨跌不一,沪银涨0.43%,螺纹跌0.16%,铁矿涨0.27%,焦炭涨0.58%,原油跌0.51%,燃油跌0.64%,橡胶涨0.25%。

株洲日报电子版阅读

福州红木家具

常见的附加费用包括医疗、护理、购置助能设备等费用。特别是在机构养老服务中,老年人的身体健康和生活习惯都需要高度的重视,因此附加费用也相应越来越多。

其次是实木茶盘可以吸收水分,更加刻画出茶水的差异。当茶水流逝之际,茶盘会渐渐被浸湿,像人类的脉络一样,逐渐呈现出自然而然的图案。同时,茶盘还具有简洁、美观的外形,作为装饰和欣赏的对象,也很受爱好者的喜爱。

开店时的前期投入是必不可少的,这其中装修和设备采购便是必不可少的一项。在运营前期,顾客首先会被门面的光鲜亮丽所吸引,因此店铺装修显得尤为重要。同时还需要采购沙发、桌椅、冰霜机等各种设备,将需要花费一笔不小的成本。

莱钢招工招聘80人

高清电视播放器

综上所述,冶金机械网作为一个专业的行业信息交流平台,具备提供设备展示和销售、技术咨询以及行业交流等服务。通过该平台,用户可以更方便地了解到冶金行业内最新的技术和应用情况,为企业和个人提供更高效的生产和学习支持。

冶金石灰和石灰是两种常见的化学物质,它们在很多领域都有着重要的应用,但它们之间也存在着一些区别。在本文中,我们将会探讨这些区别。

这家职业装专卖店位于天津市中心的商业区,店面大小适中,展示了各种不同类型的职业装,从正式到休闲、从冬季到夏季都有涵盖。店内装饰简洁又时尚,墙面用大理石做装饰,显得高档而大气。整个店铺用的灯光明亮,给人感觉舒适明快。居民和游客都可以轻松找到这家店,因为周围的地标建筑物很多。

农家小地主的创业历程

抗战之真心英雄

影片《鏖战特攻》是范·迪塞尔自编自导自演的动作片。故事讲述了一个海豚训练员(范·迪塞尔 饰)为拯救他的女朋友(奥卡·布鲁克斯 饰)被迫加入特殊部队参加激烈的军事行动。这场战斗将决定整个世界是否能获得自由和幸福。

许多人可能认为,刺绣只是简单地刺几笔针线。但是,刺绣实际上是一项极其有技术含量的手艺。在洛桑学艺的这个巴洛克建筑中,我们可以看到各种各样的刺绣作品。这些精美的作品,都是由洛桑学艺的手工艺人亲自制作的。不仅如此,他们还会把自己的知识、经验和技能传授给后人,保持着这项传统手工艺术活力与活跃。

多元化服务

搜狗小说

无论如何,《极品人生兑换系统》作为一部创作精良、引人深思的小说,已经成为了都市小说的代表之作。它将一些看似普通的物质和精神需求,通过手法生动的描写,打造成了一个充满奇幻、超现实色彩的虚拟人生世界,令读者对现实生活有了新的感悟和思考。

在现如今的网络社交时代,一个好的人设可以带给读者愉悦的感受,而极品人设更是能够深深地打动我们的内心。然而,许多小伙伴们都有着同样的担忧,那就是极品人设是否会出现崩塌的情况呢?本文将为大家详解,为什么有些人的极品人设不能崩,以及如何才能在自己的人设上做到不易倒塌。

LUSHANG FREDA(600223)3Q23 EARNINGS REVIEW:REVENUE BEATS ALONG WITH TURNING POINTS IN OPERATIONS BUSINESS COVERAGE

  In 3Q23, the cosmetics business revenue exceeded expectations with personnel adjustments settled, and turning points in operations and business coverage have both arrived. Against the backdrop of consumer demand falling under pressure, Rellet and Dr.Alva achieved quarterly growth of 44% and 34%, respectively, along with a significant improvement in gross profit margin (GPM). For the pharmaceutical business, Lushang Freda has been expanding its sales channels, enhancing R&D, and gradually launching new products to drive incremental growth; the quarterly revenue pressure may have reflected the impact of the crackdown on healthcare corruption. The raw material business has been continuously optimized by focusing on high-value raw materials, expanding product categories, and entering new fields. With the Company's core business refocused, personnel adjustments finalized, and teams and personnel optimized, we expect its operational efficiency to continue to improve, enhancing long-term growth visibility. We maintain our target price at Rmb13 and reiterate the "BUY" rating.  Reporting steady growth and optimized profitability after adjusting for the disposal of real estate assets. p 3Q23 report overview: In 1-3Q23, Lushang Freda achieved operating revenue of Rmb3.395bn (-60.20% YoY or +15.42% YoY on a comparable basis), a GPM of 47.08% (+21.00ppts YoY or +3.42ppts on a comparable basis), attributable net profit (ANP) of Rmb238mn (+54.79% YoY), and a net profit margin (NPM) of 7.01% (+4.83ppts YoY), while its ex-one-off net profit reached Rmb108mn (-33.17% YoY), implying an ex-one-off NPM of 3.17% (+1.28ppts YoY). In 3Q23 alone, the Company achieved operating revenue of Rmb922mn (-75.05% YoY or +18.24% YoY on a comparable basis), a GPM of 54.91% (+35.13ppts YoY or +6.32ppts YoY on a comparable basis), ANP of Rmb47.61mn and an NPM of 4.85%, while its ex-one-off net profit stood at Rmb44.71mn, leaving the ex-one-off NPM at 4.85%. p After adjusting for the disposal of real estate assets: In 1-3Q23, Freida Pharmaceutical Group, the entity that holds the majority of the cosmetic, pharmaceutical and raw material businesses after excluding the real estate business, achieved operating revenue of Rmb2.159bn (+15.95% YoY), net profit of Rmb156mn (+24.89% YoY), and an NPM of 7.23% (+0.51ppts YoY). In 3Q23 alone, Freida Pharmaceutical Group achieved operating revenue of Rmb690mn (+19.58% YoY), net profit of Rmb37mn (+85.00% YoY), and an NPM of 5.36% (+1.90ppts YoY). p Adjusted performance: During the reporting period, the Company's revenue and net profit declined along with cost optimization, affected by the divestment of its real estate business. However, when considering comparable revenue figures for the cosmetics, pharmaceutical, and raw material segments, the Company has shown a trajectory of steady growth, with a significant improvement in GPM.  Cosmetics: Rellet and Dr.Alva delivered strong growth in 3Q23, aided by a boost to the GPM thanks to an optimized product structure.  In 1-3Q23, the Company's cosmetics business achieved operating revenue of Rmb1.654bn (+15.75% YoY) along with a GPM of 62.08% (+3.52ppts YoY). In 3Q23 alone, the cosmetics business achieved operating revenue of Rmb548mn (+31.41% YoY) with the GPM at 60.14% (+6.80ppts YoY). 1) Rellet witnessed substantial growth in 3Q23 on the back of a ramp-up in new product sales and channel optimization. The Rellet brand achieved operating revenue of Rmb612mn (+13.33% YoY) in 1-3Q23 and Rmb220mn (+44.32% YoY) in 3Q23 alone. During the reporting period, Rellet's spray sales soared by 406% YoY, and new products such as moisturizing cream and mask powder performed well. As the Company optimized its sales channels, Rellet's self-operated online sales surged by 129.38% in 1-3Q23. 2) Dr.Alva maintained rapid growth and launched new mid-to-high-end products. The Dr.Alva brand achieved operating revenue of Rmb893mn (+19.87% YoY) in 1-3Q23 and Rmb295mn (+33.95% YoY) in 3Q23 alone.  During the reporting period, Dr.Alva upgraded its probiotic face mask to 2.0 and introduced a new moisturizer to improve its mid-to-high-end product lineup. As of the end of 3Q23, it had sold 160k bottles of the new moisturizer.  It also introduced new products such as wake-up essence and anti-acne essence to boost the brand's growth and efficiency. 3) The comprehensive "4+N" brand matrix addresses segmented consumer demand, contributing to the Company's overall growth backed by a multi-brand portfolio. Other brands achieved operating revenue of Rmb149mn (+3.47% YoY) in 1-3Q23 and Rmb33mn (-26.67% YoY) in 3Q23 alone. 4) Lushang Freda is accelerating its entry into the medical aesthetics market, with the collagen production line already in place. The Company is advancing medical aesthetic equipment production and technology development and has completed the construction of collagen raw material and Class II & Class III medical equipment production lines. In terms of products, the Company has obtained a medical device registration certificate for its hyaluronic acid sodium solution (Class II). through enhanced R&D. Raw materials: Focusing on new product development and expanding application scenarios. 1) The pharmaceutical business continued to expand channels and strengthen R&D efforts. In 1-3Q23, the Company's pharmaceutical business achieved operating revenue of Rmb399mn (+18.48% YoY) with a GPM of 54.42% (+2.10ppts YoY). In 3Q23 alone, the pharmaceutical business achieved operating revenue of Rmb108mn (-14.29% YoY) with a GPM of 49.41% (+0.07ppts YoY). The revenue pressure in 3Q23 may have been influenced by anti-corruption measures in the pharmaceutical sector, but a return to normal levels looks imminent. In terms of sales channels, the Company's pharmaceutical business has continued to expand into above-county-level and higher-level hospitals, grassroots medical institutions, and pharmaceutical chains, while also accelerating the ecommerce sales of supplementary over-the-counter (OTC) drugs. On the R&D front, the Company has established a contract development and manufacturing organization (CDMO) platform for drug pilot testing and production conversion. It is also accelerating R&D innovation and has obtained a drug registration certificate for Tadalafil tablets, which are now available for sale, during the reporting period.  2) The raw material business is actively pushing for registrations, launching new products and enhancing synergies. In 1-3Q23, the Company's raw material business achieved operating revenue of Rmb253mn (+9.13% YoY) with a GPM of 36.01% (+3.54ppts YoY). In 3Q23 alone, the raw material business achieved revenue of Rmb83mn (+1.22% YoY) with a GPM of 36.97% (+5.58ppts YoY). The Company has continued to advance the registration of domestic and foreign active pharmaceutical ingredients (APIs) and develop new raw materials. During the reporting period, the focus has been on Freda's sodium hyaluronate API for eye drops, which has obtained the "In Progress" registration number from the Center for Drug Evaluation (CDE) of the National Medical Products Administration (NMPA). Freda Biotechnology's ectoine has received the FDA's Drug Master File (DMF) registration, and three new cosmetic raw materials have been introduced. In addition, the Company is continuously strengthening synergy in the raw material business, advancing cooperation on materials such as hyaluronic acid and natamycin and further expanding the application scenarios of hyaluronic acid, polyglutamic acid, and ectoine raw materials. With the divestiture of real estate assets, the Company's expense ratio is aligning with the average of the cosmetics industry, with financial expenses significantly optimized and aggressive R&D spending driving research in pharmaceuticals, raw materials, and cosmetics. 1) The Company's selling and administrative expense ratios have increased significantly, approaching the average of the cosmetic industry. In 1-3Q23, the Company's selling expense ratio was 32.04% (+20.68ppts YoY), and the administrative expense ratio was 4.63% (+1.98ppts YoY). In 3Q23 alone, the selling expense ratio was 40.06% (+31.88ppts YoY), and the administrative expense ratio was 5.24% (+2.95ppts YoY). 2) The Company has consistently adjust its debt structure, significantly optimizing its debt costs. In 1-3Q23, the Company's financial expense ratio was 1.19% (-1.35ppts YoY), and in 3Q23 alone, the financial expense ratio was -2.46% (-4.65ppts YoY). The Company has consistently optimized its debt structure. In 1Q23, the Company received net cash of Rmb1.38bn from the disposal of subsidiaries. In 2Q23, it repaid Rmb1.817bn debt in cash and obtained loans of Rmb317mn. In 3Q23, it repaid Rmb192mn debt and obtained loans of Rmb137mn. Through this debt structure adjustment, the Company's interest rate on liabilities in 1-3Q23 reached 1.22% (-1.88ppts YoY), resulting in significant optimization of debt costs. 3) The Company has continued to maintain a high level of R&D spend. In 1-3Q23, the R&D expense ratio was 2.96% (+2.03ppts YoY), and in 3Q23 alone, the R&D expense ratio was 3.87% (+3.22ppts YoY). The Company is committed to high R&D spending, focusing on pharmaceutical and cosmetic raw materials. The Company's controlling shareholder has pledged 70mn shares to issue convertible corporate bonds.  In Jun 2023, Shandong Commercial Group, the Company's controlling shareholder, announced the plan to issue convertible corporate bonds in 2023 (the first tranche), with the issuance capped at Rmb500mn, and pledged 70mn shares, equivalent to approximately 6.89% of the total shares of the Company.  Previously, Shandong Commercial Group issued convertible corporate bonds in Apr 2021, with the total amount not exceeding Rmb1.5bn. To provide guarantees for the convertible bonds, Shandong Commercial Group pledged 20mn shares in the first tranche in Sep 2021 (approximately 1.97% of the total  shares) and pledged 35mn shares in the second tranche in Dec 2021 (approximately 3.44% of the total shares). Potential risks: Industry regulation tightening; underperformance in the Company's cosmetics business; increased competition in the raw material business; unexpected drops in pharmaceutical product prices; uncertainty in pharmaceutical industry policies and the Company's technology R&D in the pharmaceutical business; underperformance of the functional raw material market; related guarantee risks. Investment recommendation: In 3Q23, the cosmetics business revenue exceeded expectations with personnel adjustments settled, and turning points in operations and business coverage have both arrived. Against the backdrop of consumer demand falling under pressure, Rellet and Dr.Alva achieved quarterly growth of 44% and 34%, respectively, along with a significant improvement in gross profit margin (GPM). For the pharmaceutical business, Lushang Freda has been expanding its sales channels, enhancing R&D, and gradually launching new products to drive incremental growth; the quarterly revenue pressure may have reflected the impact of the crackdown on healthcare corruption. The raw material business has been continuously optimized by focusing on high-value raw materials, expanding product categories, and entering new fields. With the Company's core business refocused, personnel adjustments finalized, and teams and personnel optimized, we expect its operational efficiency to continue to improve, enhancing long-term growth visibility. We maintain our 2023E/24E/25E revenue forecast at Rmb4.207bn/5.350bn/6.504bn and ANP forecast at Rmb386mn/498mn/610mn, corresponding to EPS forecast of Rmb0.38/0.49/0.60. With the valuation of comparable peers in the cosmetic and raw material industries as a reference, with Proya (603605.SH), Bloomage Biotech (688363.SH), and Marubi (603983.SH) trading at 34x 2023E PE on average based on Wind consensus estimates, we assign 34x 2023E PE to keep our target price unchanged at Rmb13 and reiterate the "BUY" rating. 【免责声明】本文仅代表第三方观点,不代表和讯网立场。投资者据此操作,风险请自担。

乙烯合成乙二醇合成路线

玉柴柴油机

尽管印刷标书是最具参考性的文件,但是在投标过程中,常常会发生查看标书的人员不能解读、混淆或丢失其中的某些信息的情况。此外,由于某些细节可能必须在交易的前期就得到确定,而前期可能还没有确切的信息,这也可能导致涵盖不完整的情况。针对这种情况,一些商业公司可能会在提交正式标书前提前开展专门的问答和技术会议,以确保提交的标书准确无误。

唯美度美容院使用最高品质的护肤、化妆和美发产品,确保每一次服务都能带来最好的效果。这些产品经过专业筛选,是市面上最受欢迎的品牌之一,同时也是唯美度美容院的信条,不仅提供更绿色的产品,更注重产品的营养和效果,让顾客得以体验最好的美容护理。

黑管和单簧管的区别

爱菲烟克

将卫生纸卷筒变身为一款可爱的笔筒,只需要简单的装饰就可以了。首先,将卷筒用底色涂上颜色,然后用彩纸剪出自己喜欢的图案,如小兔子、小狗狗等,用胶水粘贴到卷筒上,再用一些可爱的小装饰点缀即可。

总之,塑料格栅网的出现极大提高了我们的建筑和土地环境安全水平,随着应用领域的扩大和需求量的增加,它的市场前景也将越来越广阔。

塑料桶灌装机是一种可以自动化完成灌装工作的机器,可以广泛应用于化妆品、食品、医药等行业中。它的主要作用是将各种物质(液态或粉状)灌装到包装盒中,并封口,生产出一定的成品。

庆余年小说的魅力

国产网曝门亚洲综合在线

机器人的第一条原则是保护人类。这个原则的意义在于防止机器人在执行任务时伤害或杀害人类。这种可能性常常被误解为科幻电影中虚构的“机器人反叛”,但事实是机器人很容易因意外或缺陷而对人类造成伤害。如今,随着机器人被广泛应用于各个领域,如工业、医疗保健和家庭服务,现实世界中这种情况不断发生。因此,保护人类是机器人技术发展的基础,也是机器人与人类协作的必要条件。

此外,许多粉丝甚至开始质疑胡图图牛爷爷在不断转型中的行为,例如是否符合自己的人设,亦或者是应该回到专注于描绘友情和情感的原初状态。因此也有不少网友调侃:“我们谁忠于谁”、“小孩子看这些东西不好吧”,胡图图牛爷爷扮演的形象已经不再纯真简单。

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